產品編號：Y3285
英文名稱：Shikonin
CAS號 517-89-5  
分析標準品，≥98%
分子式 C16H16O5 分子量288.30

基本信息:

密度 1.373
溶解性 Soluble in DMSO (10 mg/ml).
存貯條件 儲存溫度2-8℃
描述 
別名 5,8-二羥基-2-[(1R)-1-羥基-4-甲基戊-3-烯基]萘-1,4-二酮;5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione
生化機理 Shikonin is a naturally occurring active chemical found in the root of Lithospermum erythrorhizon and used as a Chinese herb. The compound is a naphthoquinone derivative and has been shown to have anti-inflammatory and anti-tumor properties, as well as alter chemokine expression and function. Angiogenesis studies have shown that Shikonin can inhibit proliferation and migration of endothelial cells, block integrin αvβ3 expression, and inhibit B16 melanoma- and tumor necrosis factor-alpha-inuced angiogenesis in mice. Shikonin can down-regulate protein and mRNA expression of CKR-5 (CCR5), a primary HIV-1 coreceptor, in macrophages in HIV studies. Shikonin is an inhibitor of PKM2.
應用 A naphthoquinone derivative with angiogenesis inhibitor properties.