產(chǎn)品編號：Y0282

英文名稱：Cholecalciferol (D3)

CAS號 67-97-0

分析標準品

分子式 C27H44O 分子量384.64

基本信息:

敏感性  對光敏感

旋光率  108 ° (C=0.5, EtOH)

密度  0.9600

熔點  84-85°C

存貯條件  2-8°C 避光保存

描述

產(chǎn)品介紹  脂溶性維生素，不溶于水，水溶性: <0.1 g/L (20°C) 溶于醇、醚、丙酮和氯仿等大多數(shù)有機溶劑，微溶于植物油。在潮濕空氣中幾天就氧化失活，純結(jié)晶在棕色真空安瓿中冰箱相存放一年后僅有極微量變質(zhì)。

別名  維生素D3 ;膽骨化醇，活化7-去氫膽固醇，9,10-開環(huán)膽甾-5,7,10(19)-三烯-3beta-醇 ;(+)-Vitamin D3 7-Dehydrocholesterol activated Activated 7-dehydrocholesterol Calciol Cholecalciferol 9,10-Secocholesta-5,7,10(19)-trien-3beta-ol

生化機理 

Cholecalciferol is a naturally occuring form of vitamin D. Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

應(yīng)用  Vitamin D3 通過受體起作用，該受體是具配體依賴性轉(zhuǎn)錄因子大家庭的一員，調(diào)控正常細胞和癌細胞的增殖和分化，對乳腺癌、結(jié)腸癌和前列腺癌具抗增殖、抗轉(zhuǎn)移效果。腸和骨骼內(nèi)激活的Vitamin D受體還能維持鈣吸收和內(nèi)平衡。