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標(biāo)記一抗
英文名稱Anti-AE2/FITC
中文名稱:FITC標(biāo)記的陰離子交換蛋白2抗體
別 名AE 2; AE-2; AE2 anion exchanger; Anion exchange protein 2; Anion exchanger 2; B3A2_HUMAN; BND3L; EPB3L1; HKB3; MPB3L; Non-erythroid band 3-like protein; SLC4A2; Solute carrier family 4 member 2.
規(guī)格:100ul
說(shuō) 明 書(shū)100ul
研究領(lǐng)域腫瘤 心血管 細(xì)胞生物 通道蛋白
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng) Human,
產(chǎn)品應(yīng)用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量137kDa
細(xì)胞定位細(xì)胞膜
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AE2/SLC4A2
亞 型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹background:
Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors, including hormones, innervation/neuropeptides and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of bile-salt independent flow. Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms, which involve chloride efflux through activation of chloride channels and further bicarbonate secretion via AE2 (also designated SLC4A2)-mediated chloride/bicarbonate exchange. The AE2 protein regulates pH, chloride concentration, cell volume and transepithelial ion transport in many tissues. Gene silencing of AE2 causes a marked inhibition of unstimulated and secretin-stimulated chloride/bicarbonate exchange, which maintains the bile acid pool that is crucial for secretin to induce bicarbonate-rich choleresis
Function:
Plasma membrane anion exchange protein of wide distribution.
Subcellular Location:
Membrane.
Similarity:
Belongs to the anion exchanger (TC 2.A.31) family.
中文名稱:FITC標(biāo)記的陰離子交換蛋白2抗體
別 名AE 2; AE-2; AE2 anion exchanger; Anion exchange protein 2; Anion exchanger 2; B3A2_HUMAN; BND3L; EPB3L1; HKB3; MPB3L; Non-erythroid band 3-like protein; SLC4A2; Solute carrier family 4 member 2.
詳細(xì)介紹：
規(guī)格:100ul
說(shuō) 明 書(shū)100ul
研究領(lǐng)域腫瘤 心血管 細(xì)胞生物 通道蛋白
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng) Human,
產(chǎn)品應(yīng)用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量137kDa
細(xì)胞定位細(xì)胞膜
性 狀Lyophilized or Liquid
濃 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human AE2/SLC4A2
亞 型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關(guān)資料：
產(chǎn)品介紹background:
Primary canalicular bile undergoes a process of fluidization and alkalinization along the biliary tract that is influenced by several factors, including hormones, innervation/neuropeptides and biliary constituents. The excretion of bicarbonate at both the canaliculi and the bile ducts is an important contributor to the generation of bile-salt independent flow. Bicarbonate is secreted from hepatocytes and cholangiocytes through parallel mechanisms, which involve chloride efflux through activation of chloride channels and further bicarbonate secretion via AE2 (also designated SLC4A2)-mediated chloride/bicarbonate exchange. The AE2 protein regulates pH, chloride concentration, cell volume and transepithelial ion transport in many tissues. Gene silencing of AE2 causes a marked inhibition of unstimulated and secretin-stimulated chloride/bicarbonate exchange, which maintains the bile acid pool that is crucial for secretin to induce bicarbonate-rich choleresis
Function:
Plasma membrane anion exchange protein of wide distribution.
Subcellular Location:
Membrane.
Similarity:
Belongs to the anion exchanger (TC 2.A.31) family.
