英文名稱：Evodiamine  
CAS號(hào)：518-17-2
分析標(biāo)準(zhǔn)品,≥99%  
分子式 C19H17N3O 分子量303.36  

基本信息:

敏感性   對(duì)光敏感
密度  1.39
熔點(diǎn)   278°C
溶解性   Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25 °C, and ethanol (<1 mg/mL) at 25 °C
存貯條件   陰涼干燥，避光保存
描述  
產(chǎn)品介紹   Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects.
別名   吳茱萸胺;
生化機(jī)理   The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis through inhibition of vascular endothelial growth factor gene expression and inhibition of the ERK 1 (p44)/ERK 2 (p42) mitogen-activated protein kinase that correlated to endothelial cell angiogenesis. Promotion of apoptosis in human leukemic U937 cells is described with Evodiamine.
應(yīng)用   An antiangiogenic and antiinflammatory agonist of TRPV1.