英文名稱：Indirubin  
CAS號(hào)：479-41-4
分析標(biāo)準(zhǔn)品,≥95%  
分子式 C16H10N2O2 分子量262.26  

基本信息:

敏感性   對(duì)熱敏感
密度  1.417
溶解性   Soluble in DMSO(warmed) (>2 mg/ml).
存貯條件   儲(chǔ)存溫度2-8℃
描述  
產(chǎn)品介紹   Indirubin, also known as isoindigotin, is an inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50 = 10μM), CDK2/cyclin A (IC50 = 2.2μM), CDK2/cyclin E (IC50 = 7.5μM), CDK4/cyclin D1 (IC50 = 12μM), CDK5/p35 (IC50 = 5.5μM)) and of GSK-3β (IC50 = 600nM). Studies investigating functional isoindigos show that they have the ability to disrupt cell growth and proliferation. The compound is a potent aryl hydrocarbon receptor ligand and is found in human urine and fetal bovine serum. Synthesized isoindigo-based oligothiophenes are used to study heterojunction solar cells. Shown to inhibit allergic contact dermatitis by regulating T helper mediated immune system in a DNCB-induced model.
別名   靛紅 ;Indigo Red; Isoindogotin
應(yīng)用   An inhibitor of GSK-3β and cyclin-dependent kinases.